– Tylosin is a macrolide antibiotic produced by a strain of Streptomyces fradiae.
– At normal doses, tylosin has a bacteriostatic action. It inhibits the synthesis of proteins susceptible organisms by binding to 50S ribosomal subunits and blocking the step translocation.
Tylosin binds reversibly to the 23S rRNA in the 50S ribosome subunit and inhibit mRNA-directed protein synthesis. They also stimulate the dissociation of peptidyl-tRNA from ribosomes during translocation.
Tylosin has spectrum activity includes Gram-positive bacteria such as Clostridium perfringens and some Gram-negative strains such as Pasteurella and Mycoplasma spp. at concentrations of 16μg/ml or less.
1) Broilers Chickens:
a)Treatment of chronic respiratory disease (CRD) caused byMycoplasma gallisepticum in chickens. 2) Pigs:
a) Treatment of swine dysentery Caused by Brachyspirahyodysenteriae.
b) Treatment of enzootic pneumonia Caused by Mycoplasma hyopneumoniae. Target species:
c) Broilers Chickens and pigs.
Route: Orally via drinking water. For Whole Product: Broilers Chickens: 2 – 1.2 gm / liter per day added to the drinking water for 2 to 5 days. Pigs: 80 – 40 mg / kg of body weight per day. Use only medicinal water for 3 to 10 days maximum. Fattening turkeys: 24.59 gm-32.79 gm of product / 1000 kg.b.wt. in drinking water /day /5 days(0.35-0.25 gm/liter). Pigs: 2 gm of product/ 61 kg.b.wt. in drinking water/day/4 days.
- It is advisable to periodically check the susceptibility of isolated pathogens in vitro.
- The drinking water facilities (water tank, pipes, nipples etc...) must be carefully cleaned after the end of treatment.
Do not administer to laying hens producing eggs for human consumption.
Do not use in animals with known hypersensitivity to Tylosin.
Do not administer Tylosin with coccidiostats feed additives because Tylosin is
compatible with most coccidiostats feed additives.
Do not administer Tylosin with lincomycin which may lead to antagonism.