Florfenicol is a broad-spectrum synthetic antibiotic in the phenicol group that is active
against most Gram-positive and Gram-negative bacteria isolated from domestic animals.
Florfenicol acts by inhibition of protein synthesis at the ribosomal level and is bacteriostatic.
However, bactericidal activity has been demonstrated in-vitro against Actinobacillus pleuropneumoniae and Pasteurella multocida when florfenicol is present at concentrations above the MIC for up to 12 hours.
In-vitro testing has shown that florfenicol is active against the bacterial pathogens most commonly isolated in respiratory diseases in pigs, including Actinobacillus pleuropneumoniae and Pasteurella multocida.
- A slight reduction of water consumption by the animals, dark brown faeces and constipation may be observed during treatment. Commonly observed adverse effects are diarrhoea and/or peri-anal and rectal erythema/oedema which may affect approximately 40% of the animals.
- These effects are transient.
- In a few of the affected animals prolapse of the rectum that resolves without treatment may be observed.
- In case of overdosing, a decrease in weight gain, food and water consumption, peri-anal erythema and edema and modification of some hematological and biochemical parameters indicative of dehydration may be observed.
- Its use is not recommended during gestation and lactation.
- Use of the product should be based on susceptibility testing.
- Inappropriate use of the product may increase the prevalence of bacteria resistant to florfenicol.
- Treatment should not exceed 5 days.
- The medicated drinking water should be replaced every 24 hours.