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For the treatment of: - Omphalitis, or (Navel ill, “Mushy chick” disease, Yolk sac
infection): caused by infection with S aureus - Colibacillosis (Colisepticemia, Escherichia infection): caused
by infection with Escherichia coli - Erysipelas disease caused by infection with Erysipelothrix
- Paratyphoid Infections: caused by infection with S
Typhimurium, S Enteritidis - Fowl Cholera caused by infection with Pasteurella multocida
Each 1ml contains: Sulfadiazine 400 mg Trimethoprim 80 mg
Properties: - Sulfadiazine is a sulfonamide antibiotic
- Trimethoprim is a diaminopyrimidine antimicrobial
agent which is effective against wide range of both Gram - positive
and-negative organism - Folates are essential to the bacterial/protozoal cell for
multiplication and survival. - Sulphadiazine prevents the bacterial/protozoal cell from
synthesising folic acid.- Trimethoprim prevents the conversion of folic acid to folinic
acid in the bacterial/protozoal cell, by inhibiting the bacterial/protozoal
enzyme-dihydrofolate reductase - Trimethoprim – sulphonamide: - The two active ingredients produce a sequential double blockade
of bacterial synthesis of folinic acid, giving a level of activity many times
greater than either drug alone. - The action of this combination is bactericidal, where as the
components used separately are generally bacteriostatic. Potentiation is shown
even against bacteria that are generally resistant to one or other of the
components. - Trimethoprim – sulfadiazine antibacterial spectrum covers a
range of both Gram - positive and -negative microbes. Usually sensitive to the following Gram positive bacteria: S.
aureus, Streptococcus sp., Actinomyces sp., Corynebacterium sp. E.
rhusiopathiae, L. monocytogenes. and Gram negative bacteria as follows: Actinobacillus
sp.; Bordetella sp. and Enterobacteriaceae: E. coli, Klebsiella sp. Proteus sp.
Yersinia sp.; Haemophilus sp. Susceptible anaerobic bacteria include: Actinomyces
sp., Bacteroides sp.; Fusobacterium sp. and some of the Clostridium sp.
Dosage of Administration:
Route: Orally via drinking water For Whole Product: Broiler chickens:1.56 ml per 5 liters daily for
Warning and precautions :
- All other sources of water should be removed during the entire
period of treatment. - Sulfonamide-containing products may interact with methotrexate,
phenylbutazone, phenytoin, and salicylates. - Sulfonamide-containing products should not be used at the same
time: procaine or other p-amino benzoic acid or its derivatives containing
drugs. - To avoid the possibility of crystalluria, adequate water intake
is essential. - Use of the product should be based on susceptibility testing and
take into account official and local antimicrobial procedures
Contra – Indications:
- Don't use in birds which are producing eggs or may in the future
produce egg or egg products for human consumption. -Don’t mix with other drinking water medication (note squaps on
crop milk cannot be effectively medicated by drinking water medication of
parent birds.)- Do not use in animals with known hypersensitivity to the active ingredients. - Do not use in cases with severe liver parenchymal damage.
May occur: polyarthritis, vomiting, loss of appetite,
diarrhea, and fever. Anaphylaxis and other hypersensitivity reactions
are possible. Sulfonamide-containing products can cause crystalluria
Broiler chickens (Meat): - Don’t use less than 10 days before slaughter for human
Store at temperature not exceeding 30°C.
White HDPE plastic bottle contain 100 ml oral suspension closed
with white HDPE plastic cap and PTFE(polytetrafluoroethylene)plastic internal
foam linerwith outer label .