Indication: 

Chickens: For the treatment of respiratory disease in chicken flocks as Chronic respiratory disease, Infectious sinusitiscaused by Mycoplasma gallisepticum andInfectious synovitis caused by M. synoviae. 
Turkeys: For the treatment of respiratory disease in turkey flocks as Chronic respiratory disease, Infectious sinusitiscaused by Mycoplasma gallisepticum andInfectious synovitis caused by M. synoviae. 
Calves (non ruminating): For the treatment of bovine respiratory disease as Enzootic Pneumonia and Shipping Fever Pneumonia caused byMannheimia haemolytica, Pasteurella multocida, Mycoplasma bovis. 
Pigs: For the treatment of respiratory disease in pig herds, as: Enzootic pneumonia caused by Mycoplasma hyopneumoniae, Pasteurellosis caused by Pasteurella multocida, Pleuropneumonia caused by Actinobacillus pleuropneumoniae.   

Composition:
Each 1 ml contains:
Tilmicosin phosphate 250 mg (Eq. to Tilmicosin base 224.66 mg)  

Properties:
Tilmicosin is a mainly bactericidal semi-synthetic antibiotic of the macrolide group. It is believed to affect protein synthesis. It has bacteriostatic action but at high concentrations it may be bactericidal. This antibacterial activity is predominantly against Gram-positive microorganism with activity against certain Gram-negative ones and Mycoplasma of a bovine and ovine origin. In particular its activity has been demonstrated against the following micro-organism:  Mannheimia, Pasteurella, Actinomyces (Corynebacterium), Fusobacterium, Dichelobacter, Staphylococcus, and Mycoplasma organisms of bovine and ovine origin.   

Target species:
Chickens, Turkeys, Calves (non ruminating) and Pigs.    

Dosage of Administration:

Pigs: 
To be included in the drinking water to provide a daily dose 6.67 -8.9 ml /100 kg B.W. for 5 days. 
Chickens (except hens producing eggs for human consumption): 
To be included in the drinking water at a daily dose of 0.6 – 0.9 ml / liter for 3 days. 
Turkeys: 
To be included in the drinking water at a daily dose of 0.45 -1.2 ml / liter for 3 days. 
Calves (non ruminating): 
To be included in milk replacer only, at a dose of 1.1 ml of product every 20 kg bodyweight twice daily for 3-5 consecutive days.  .  

Warning and precautions: 
Important: Must be diluted before administration to animals. Pigs, chickens and turkeys: Water consumption should be monitored in order to guarantee adequate dosing. 
In case water consumption does not match quantities for which recommended concentrations were calculated, the concentration of Tilmicosin has to be adapted in a way that the recommend dosage will be taken up by the animals or different medication should be considered. Severely ill individuals tend to drink less and may need simultaneous treatment, preferably by parenteral medication. The use of the product should be based on susceptibility tests.   

Contra - Indications: 
Do not allow horses and other equines access to drinking water containing tilmicosin. 
Do not use in case of hypersensitivity to tilmicosin or to any of the excipients. 
Do not administer to ruminating animals with active rumen function. 
Not authorised for use in laying birds producing eggs for human consumption. 
Do not use within 14 days of onset of the laying. 
Not authorised for use in lactating animals producing milk for human consumption.    

Adverse Effects: 
In very rare cases (less than 1 animal in 10,000 animals, including isolated reports), a decrease in water intake has been observed.    

Withdrawal times: 
Meat and offal of: 
Chickens: 12 days. 
Turkeys: 19 days. 
Calves: 42 days. 
Pigs: 14 days
  
Storage conditions: 
Store at temperature not exceeding 30ºC.    

Packaging: 
White HDPE plastic bottle contain 20, 50, 100, 200, 250, 500 and 1000 ml oral solution closed by white HDPE plastic cap, lined inside with LDPE foam liner and red HDPE plastic ring with an outer label and insert.