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Cattle: For the
treatment of gastrointestinal nematodes, lungworms, warble flies, mites
and lice (as shown below) of beef and non-lactating dairy cattle:
worms (adults and 4th stage larvae): Ostertagia
ostertagi, Ostertagia lyrata, Haemonchus placei, Trichostrongylus colubriformis,
Cooperia oncophora (adults), Cooperia punctata (adults),
Cooperia pectinata (adults), Bunostomum phlebotomumOesophagostomum
(adult and 4th stage larvae): Dictyocaulus viviparus Warble
flies (parasitic stages): Hypoderma bovis, H. lineatum Mites: Psoroptes
ovis, Sarcoptes scabiei var. bovis Sucking
lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes
capillatus May also
be used as an aid in the control of the mange mite Chorioptes bovis but
complete elimination may not occur.
at the recommended dose rate prevents re-infection with Haemonchus placei, Cooperia oncophora, Cooperia pectinata and Trichostrongylus
axei for 7 days after treatment, Ostertagia ostertagi and Oesophagostomum
radiatum for 14 days after treatment and Dictyocaulus viviparus for
21 days after treatment.
treatment of psoroptic mange (sheep scab), gastrointestinal nematodes,
lungworms and nasal bots of sheep:
roundworms (adults): Ostertagia
circumcincta, Haemonchus contortus, Trichostrongylus axei, T. colubriformis and
curticei, Nematodirus filicollis Variable activity
may be observed against Cooperia curticei and Nematodirus filicollis.
Lungworms: Dictyocaulus filaria (adults)
mites: Psoroptes ovis Nasal
bot: Oestrus ovis (all larval stages)
Properties: Ivermectin is a macrocyclic lactone derivative and acts by
inhibiting nerve impulses. It binds selectively and with high affinity to
glutamate-gated chloride ion channels which occur in invertebrate nerve and
muscle cells. This leads to an increase in the permeability of the cell
membrane to chloride ions with hyperpolarization of the nerve or muscle cell,
resulting in paralysis and death of the relevant parasites. Compounds of
this class may also interact with other ligand-gated chloride channels, such as
those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
and Administration: Routeof
single administration only (except for the treatment of Psoroptes ovis infections in sheep).
Cattle: Inject subcutaneously in front of, or behind, the shoulder
using aseptic technique.
Sheep: Subcutaneously in the neck, using aseptic precautions
For active ingredient:
Cattle and Sheep: 200
micrograms ivermectin per kg bodyweight. For Whole Product:
1.0 ml per 50 kg bodyweight.
0.5 ml per 25
kg of bodyweight.
-For the treatment of gastrointestinal roundworms, lungworms and
nasal bots inject once subcutaneously in the neck, using aseptic precautions; -For the treatment of Psoroptes ovis (sheep scab), two
injections with a seven day interval are required to treat clinical signs of
scab and to eliminate living mites. -For young lambs weighing
less than 20.0 kg give 0.1 ml per 5 kg.
Warning and precautions:
Care should be taken to avoid the following practices because they
increase the risk of development of resistance and could ultimately result in
ineffective therapy: -Too frequent and repeated use of anthelmintics from the same
class, over an extended period of time. -Underdosing, which may be due to underestimation of bodyweight,
misadministration of the product, or lack of calibration of the dosing device
(if any)-The shedding of nematode eggs can continue for some time after
In Cattle: To avoid secondary reactions due to the death of
Hypoderma larvae in the oesophagus or in the spine, it is recommended to
administer the product at the end of warble fly activity and before the larvae
reach their resting sites.
Swab septum before removing each dose.
The product can be administered during pregnancy in cows, ewes and
The fertility of males is not affected by administration of the
Contra - Indications:
Do not use in lactating dairy cows and sheep producing milk for
human consumption. Do not use in non-lactating dairy cows, including pregnant dairy
heifers or non-lactating dairy sheep within 60 days of calving/lambing.Do not use in cases of known hypersensitivity to ivermectin. Do not administer by the intravenous or intramuscular route. Do not combine ivermectin treatment with vaccination against
lungworms. If vaccinated animals are to be treated, treatment should not be
carried out within a period of 28 days before or after vaccination.
Transitory discomfort has been observed in some animals
immediately following subcutaneous administration. In cattle this may
include jumping and rolling, but behaviour returns to normal after 15 minutes.
Soft tissue swelling and thickening of the skin at the injection
site has been observed in treated animals. Typically these reactions are
transient and disappear within one to four weeks.
Meat and offal: 49 days. Sheep:
Meat and offal: 42 days.
Store at temperature not exceeding 30ºC, in dry place and to be
used immediately after opening.
Clear colorless glass type II of 10, 20, 30, 50, 100, 250 and 500
ml and 1 L.