Indication: 

Horse: 
Treatment of Strangles disease caused by Streptococcus equi. 
Treatment of Bacterial enterocolitis in neonatal foalscaused by Salmonella spp., Escherichia coli, and Actinobacillus spp. 

Cattle: 
Treatment of shipping fever complex caused by Pasteurellamultocida and foot rotcaused by Staphylococcus aureusEscherichia coli.

Composition:
Each 1 ml contains: 
Sulfadiazine 200 mg Trimethoprim 40 mg 

Properties: 
Sulfadiazine is a bacteriostatic antibiotic belonging to the sulphonamide group which acts by interference with the synthesis of nucleic acids. Trimethoprim is a reductase inhibitor which also interferes with the synthesis of bacterial nucleic acids. 
The trimethoprim-sulfadiazine combination derives its activity from the fact that the drugs act together with a unique "double blockade" of action.  
Each drug inhibits a different step in the biosynthetic pathways used by micro-organisms in the synthesis of reduced folate co-factors.  
Sulfadiazine inhibits the incorporation of para-aminobenzoic acid into folic acid and trimethoprim greatly potentiates the antimicrobial activity of sulphonamides both in vitro and in vivo, resulting in a synergistic effect.  
The combination presents a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria. 
The in vitro spectrum of activity includes both Gram positive and Gram negative organisms including: Actinobacilli, Actinomycae, Bordetella spp., Brucella, Corynebacteria, Escherichia coli, Haemophilus spp., Klebsiella spp., Pasteurella spp., Pneumococci, Proteus, Salmonella spp., Staphylococci, Streptococci. 

Target species: 
Horses and Cattle. 

Dosage and Administration: 
Route of administration: 
For intramuscular, intravenous or subcutaneous use. 
For active ingredient: 
Cattle: 
15 mg of active ingredients (2.5 mg trimethoprim / 12.5 mg sulfadiazine) per kilogram bodyweight once by intramuscular or slow intravenous injection, but in severe infections it may be repeated daily until 2 days after symptoms resolve up to a maximum of 5 days. The product may be administered by intravenous injection when rapid blood levels of trimethoprim and Sulfadiazine are required. 
Horses: 
15 mg of active ingredients (2.5 mg trimethoprim / 12.5 mg sulfadiazine) per kilogram bodyweight, by slow intravenous injection. 

For Whole Product: 
Cattle: 
1 ml per 16 kg bodyweight once by intramuscular or slow intravenous injection, but in severe infections it may be repeated daily until 2 days after symptoms resolve up to a maximum of 5 days. The product may be administered by intravenous injection when rapid blood levels of trimethoprim and Sulfadiazine are required. 
Horses
1 ml per 16 kg bodyweight, by slow intravenous injection. 

Warning and precautions: 
- Adequate drinking water should be available during the therapeutic effect of the product. 
- The product can be safely administered to pregnant and lactating animals. 
- Do not use in case of hypersensitivity to the active substances or to any of the excipients. 
- Do not use in animals with severe liver or renal damage or blood dyscrasias. 
- Do not use in case of reduced water intake or losses of body fluid. 
- Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. 
- Intravenous administration should be used with extreme caution and only if therapeutically justified. 

Contra - Indications: 
- The product should not be given by routes other than those recommended.   
- Not to be administered intraperitoneally. 
- Do not use in animals with known sulphonamide sensitivity, severe liver parenchymal damage or blood dyscrasias. 
- Do not administer to horses exhibiting drug-induced cardiac arrhythmias. Such arrhythmias may be associated with the administration of certain anaesthetic and sedative agents. 
- Local anaesthetics from the group of para-aminobenzoic acid esters (procaine, tetracaine) can locally inhibit the effect of sulfonamides. 
- Do not combine with other veterinary medicinal products. 

Adverse Effects: 
Anaphylactic shock has been observed on rare occasions following administration of potentiated sulphonamide preparations, mostly after intravenous injection.
For intravenous administration the product should be warmed to body temperature and injected slowly over as long a period as is reasonably practical. At the first sign of intolerance the injection should be interrupted and shock treatment initiated. 

Withdrawal times: 
Cattle
Meat and offal:  12 days 
Milk: 48 hours 
The horse must have been declared as not intended for human consumption. 

Storage conditions: 
At temperature not exceeding 30°C and to be used immediately after opening. 

Packaging: 
Glass vials 20, 30, 50, 100, 250 and 500 ml and 1 L.